Molecularly engineered materials for selective albumin binding to reduce the risk of thrombus formation

Tese de doutoramento. Engenharia Biomédica. Faculdade de Engenharia. Universidade do Porto, Instituto de Engenharia Biomédica, University of Washington Engineered Biomaterials. 200

Capacitated lot-sizing and scheduling with sequence-dependent, period-overlapping and non-triangular setups

In production planning, sequence dependent setup times and costs are often incurred for switchovers from one product to another. When setup times and costs do not respect the triangular inequality, a situation may occur where the optimal solution includes more than one batch of the same product in a single period - in other words, at least one sub tour exists in the production sequence of that period. By allowing setup crossovers, flexibility is increased and better solutions can be found. In tight capacity conditions, or whenever setup times are significant, setup crossovers are needed to assure feasibility. We present the first linear mixed-integer programming extension for the capacitated lot-sizing and scheduling problem incorporating all the necessary features of sequence sub tours and setup crossovers. This formulation is more efficient than other well known lot-sizing and scheduling models. © Springer Science+Business Media, LLC 2010

Epidemiology and demand for healthcare: an agent-based simulation model

info:eu-repo/semantics/publishedVersio

How do external and internal factors promote or hinder servitization over time? An in-depth case-study in the elevator industry

info:eu-repo/semantics/publishedVersio

Industrial insights into lot sizing and schedulingmodeling

© 2015 Brazilian Operations Research Society. Lot sizing and scheduling by mixed integer programming has been a hot research topic inthe last 20 years. Researchers have been trying to develop stronger formulations, as well as to incorporatereal-world requirements from different applications. This paper illustrates some of these requirements anddemonstrates how small- and big-bucket models have been adapted and extended. Motivation comes fromdifferent industries, especially from process and fast-moving consumer goods industries

An optimization based on simulation approach to the patient admission scheduling problem: Diagnostic imaging department case study

The growing influx of patients in healthcare providers is the result of an aging population and emerging self-consciousness about health. In order to guarantee the welfare of all the healthcare stakeholders, it is mandatory to implement methodologies that optimize the healthcare providers' efficiency while increasing patient throughput and reducing patient's total waiting time. This paper presents a case study of a conventional radiology workflow analysis in a Portuguese healthcare provider. Modeling tools were applied to define the existing workflow. Re-engineered workflows were analyzed using the developed simulation tool. The integration of modeling and simulation tools allowed the identification of system bottlenecks. The new workflow of an imaging department entails a reduction of 41 % of the total completion time. © 2013 Society for Imaging Informatics in Medicine

Asthma incidence and accuracy of diagnosis in the Portuguese sentinel practice network

Aims: Asthma is frequently under-diagnosed with a wide variation in incidence rates. We aimed to assess how physicians in a Portuguese sentinel practice network perform using standardised diagnostic criteria. Method: Patients consulting one of the 43 network physicians with complaints suggestive of asthma were enrolled in the study over a four-year period. Symptom frequency and diagnoses of asthma were tabulated. Diagnostic accuracy was computed by dividing the rate of asthma diagnosis by the true rate using established diagnostic criteria. Results: Over four years, 43 physicians followed 32,103 patients (128,412 patient-years) and diagnosed asthma in 310. The diagnosis was,confirmed in 260 cases, giving a true incidence rate of 2.02/1000/year (95% confidence interval 1.8 to 2.2) and an accuracy of diagnosis of 84%. Conclusions: Asthma incidence approaches published rates if accepted criteria are used. Educational efforts to ensure more accurate diagnosis may improve outcomes for asthma patients.Funding for the Sentinel Practice Network is provided by the Portuguese Ministry of Healtinfo:eu-repo/semantics/publishedVersio

Lotsizing and scheduling in the glass container industry

Manufacturing organizations are keen to improve their competitive position in the global marketplace by increasing operational performance. Production planning is crucial to this end and represents one of the most challenging tasks managers are facing today. Among a large number of alternatives, production planning processes help decision-making by tradingoff conflicting objectives in the presence of technological, marketing and financial constraints.Two important classes of such problems are lotsizing and scheduling. Proofs from complexity theory supported by computational experiments clearly show the hardness of solving lotsizing and scheduling problems.Motivated by a real-world case, the glass container industry production planning and scheduling problem is studied in depth. Due to its inherent complexity and to the frequent interdependencies between decisions that are made at and affect different organizational echelons, the system is decomposed into a two-level hierarchically organized planning structure: long-term and short-term levels.This dissertation explores extensions of lotsizing and scheduling problems that appear in both levels. We address these variants in two research directions. On one hand, we develop and implement different approaches to obtain good quality solutions, as metaheuristics (namely variable neighborhood search) and Lagrangian-based heuristics, as well as other special-purpose heuristics. On the other hand, we try to combine new stronger models and valid inequalities based on the polyhedral structure of these problems to tighten linear relaxations and speed up the solution process.Manufacturing organizations are keen to improve their competitive position in the global marketplace by increasing operational performance. Production planning is crucial to this end and represents one of the most challenging tasks managers are facing today. Among a large number of alternatives, production planning processes help decision-making by tradingoff conflicting objectives in the presence of technological, marketing and financial constraints.Two important classes of such problems are lotsizing and scheduling. Proofs from complexity theory supported by computational experiments clearly show the hardness of solving lotsizing and scheduling problems.Motivated by a real-world case, the glass container industry production planning and scheduling problem is studied in depth. Due to its inherent complexity and to the frequent interdependencies between decisions that are made at and affect different organizational echelons, the system is decomposed into a two-level hierarchically organized planning structure: long-term and short-term levels.This dissertation explores extensions of lotsizing and scheduling problems that appear in both levels. We address these variants in two research directions. On one hand, we develop and implement different approaches to obtain good quality solutions, as metaheuristics (namely variable neighborhood search) and Lagrangian-based heuristics, as well as other special-purpose heuristics. On the other hand, we try to combine new stronger models and valid inequalities based on the polyhedral structure of these problems to tighten linear relaxations and speed up the solution process